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Bromazolam (XLI-268) is a triazolobenzodiazepine (TBZD) that was first synthesized in 1976, but never marketed.[2] It has subsequently been sold as a designer drug and was first definitively identified by the EMCDDA in Sweden in 2016.[3] It is the bromo rather than chloro analogue of alprazolam and has similar sedative and anxiolytic effects to this and other benzodiazepines.[4][5] Bromazolam is a non-subtype selective agonist at the benzodiazepine site of GABAA receptors, with a binding affinity of 2.81 nM at the α1 subtype, 0.69 nM at α2, and 0.62 nM at α5.[6] The ‘usual’ dosage range for bromazolam users is said to be 1–2 mg, suggesting that its potency is similar to that of alprazolam.[7]